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KMID : 0356219940250010009
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Journal of the Korean Military Medical Association
1994 Volume.25 No. 1 p.9 ~ p.15
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Correlation Between Liver Histology and markers of Hepatitis B Virus Replication in Infected Patients: A Study by In Situ Hybridization
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Abstract
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Liver sections from 10 patients positive for hepatitis B e antigen(HBeAg), and from 10 negative patients, were examined for the presence of hepatitis B virus(HBV) DNA using an in situ hybridization assay that would i
dentify only those hepatocytes
containing more than 10 to 15 HBV genome equivalents per cell. Such cells are likely to be undergoing active viral replication, rather than latent infection. The findings were correlated with correlated with results of tissue staining for HBV
core
antigens(HBcAg) and the presence of serum hepatitis B e antigen(HBeAg) in hepatocytes and HBeAg serum, but not with the presence of HBsAg in hepatocytes, nor with histological evidence of disease activity judged by the presence of piece-meal
necrosis
and lobular and portal tract inflammation. These findings support the view that liver HBcAg and serum HbEAg are markers of virus replication, and demonstrate that active liver disease in HBsAg-positive patients may occur with or without such
markers of
replication. It is proposed that alternative mechanisms for hepatocyte injury may apply in different chronic HBV patients, one related to virus replication and one dependent on immunological factors.
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KEYWORD
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